Cannabis Strains for Defeating Depression


Cannabis Strains for Defeating Depression

The chronically depressed should avoid pure- or high-indica strains because of their tendency to induce “couch lock,” which can be counterproductive for someone who is already feeling depressed. Sativa, while known for leaving users energized and active, may be too invigorating. It’s best to find a hybrid that has received high ratings from users who’ve found success in beating depression. Strains high in the terpene limonene, with its sweet, citrus smell, are typically known for mood elevation.

The strains in the following list have been rated as providing considerable therapeutic relief to those who are suffering from mild to moderate levels of depression.


Dubbed the “one-hit wonder,” AK-47 has won many awards and produces a high that relaxes and relieves anxiety.

Blue Dream 

“Uplifts while easing tension, anxiety and stress”

Girl Scout Cookies  

Although Indica dominant, the relatively high sativa content eases tension, anxiety and promotes relaxation.

  • Variety: Indica-Dominant Hybrid with strong Sativa component (60:40 Indica-Sativa Ratio).
  • Origin: The strain began as a crossbreed of OG-Kush, Durban Poison It first appeared in California and is now one of the most popular strains in the U.S; particularly popular in Michigan and on the West Coast.
  • THC Range: 17 – 28 percent
  • Characteristics:

Jack Herer 

This classic was named after the influential cannabis activist and is one of the most well-known strains. It is both activating and relaxing at the same time.

  • Variety: Hybrid: (55:45 Sativa – Indica Ratio)
  • Origin: Haze, Skunk #1, Northern Lights #5
  • THC Range: 17 – 24 percent
  • Characteristics:
    • Effects: Body Buzz, Cerebral, Creative, Energized, Euphoric, Happy
    • Symptom Relief: Depression, Fatigue, Nausea, Pain, Stress
    • Flavors/Aromas: Earthy, Lemon, Pine, Spicy, Sweet

Flavors/Aromas: Earthy, Herbal, Lemon, Spicy, Sweet, Woody

Pineapple Express 

Seth Rogen and James Franco immortalized this strain in the 2008 movie of the same name.

  • Variety: Sativa-Dominant Hybrid (60:40 Sativa – Indica Ratio)
  • Origin: Trainwreck, Hawaiian
  • THC Range: 12 – 17 percent
  • Characteristics:
    • Effects: Cerebral, Clear-Headed, Energetic, Euphoric, Focused
    • Symptom Relief: Confusion, Depression, Fatigue, Nausea, Nightmares
    • Flavors/Aromas: Cedar, Earthy, Pine, Pineapple, Sweet

Sour OG

This strain is known for leaving patients feeling relaxed and peaceful while still highly productive.

  • Variety:  Balanced Hybrid (50:50 Sativa – Indica Ratio)
  • Origin: Blueberry, OG-Kush, Sour Diesel
  • THC Range: 17 percent
  • Characteristics:
    • Effects: Euphoric, Giggly, Happy, Relaxed, Social, Uplifted
    • Symptom Relief: Depression, Lack of Appetite, Nausea, Pain, Stress
    • Flavors/Aromas: Citrus, Deisel, Earthy, Pungent, Sour

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